Association of circulating leukocyte telomere length with survival in patients with colorectal cancer.

ABSTRACT:

Introduction

Telomere shortening, as seen with aging, can cause chromosomal instability and promote cancer progression. We investigated the association between circulating telomere length and overall and disease-free survival in a sub-cohort of patients with colorectal cancer.

Methods

Baseline genomic DNA from blood leukocytes was extracted from N = 92 newly diagnosed stage I-IV patients with colorectal cancer enrolled at the ColoCare Study site in Heidelberg, Germany. Detailed information on clinicodemographic (including age) and lifestyle risk factors, and clinical outcomes (including recurrence and survival) was collected. Telomere length was measured in DNA using multiplex quantitative polymerase chain reaction. Kaplan Meier survival curves were generated comparing short

SUBMITTER: Pauleck S 

PROVIDER: S-EPMC9197691 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature