[Interaction between ischemic stroke risk loci identified by genome-wide association studies and sleep habits].

ABSTRACT:

Objective

To explore the relationship between sleep habits (sleep duration, sleep efficiency, sleep onset timing) and ischemic stroke, and whether there is an interaction between sleep habits and ischemic stroke susceptibility gene loci.

Methods

A questionnaire survey, physical examination, blood biochemical testing and genotyping were conducted among rural residents in Beijing, and the gene loci of ischemic stroke suggested by previous genome-wide association studies (GWAS) were screened. Multivariable generalized linear model was used to analyze the correlation between sleep habits, sleep-gene interaction and ischemic stroke.

Results

A total of 4 648 subjects with an average age of (58.5±8.7) years were enrolled, including 1 316 patients with ischemic stroke. Compar

SUBMITTER: Yang RT 

PROVIDER: S-EPMC9197694 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature