[Association study between haplotypes of WNT signaling pathway genes and nonsyndromic oral clefts among Chinese Han populations].

ABSTRACT:

Objective

To explore whether WNT signaling pathway genes were associated with non-syndromic oral clefts (NSOC) based on haplotypes analyses among 1 008 Chinese NSOC case-parent trios.

Methods

The genome-wide association study (GWAS) data of 806 Chinese non-syndromic cleft lip with or without cleft palate (NSCL/P) trios and 202 Chinese non-syndromic cleft palate (NSCP) case-parent trios were drawn from the International Consortium to Identify Genes and Interactions Controlling Oral Clefts (ICOCs) study GWAS data set, whose Chinese study population were recruited from four provinces in China, namely Taiwan, Shandong, Hubei, and Sichuan provinces. The process of DNA genotyping was conducted by the Center for Inherited Disease Research in the Johns Hopkins University, using Illu

SUBMITTER: Wang MY 

PROVIDER: S-EPMC9197701 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature