Mendelian imputation of parental genotypes improves estimates of direct genetic effects.

ABSTRACT: Effects estimated by genome-wide association studies (GWASs) include effects of alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for example, effects of alleles in parents on offspring through the environment) and bias from confounding. Within-family genetic variation is random, enabling unbiased estimation of direct genetic effects when parents are genotyped. However, parental genotypes are often missing. We introduce a method that imputes missing parental genotypes and estimates direct genetic effects. Our method, implemented in the software package snipar (single-nucleotide imputation of parents), gives more precise estimates of direct genetic effects than existing approaches. Using 39,614 individuals from the UK Biobank with at least one g

SUBMITTER: Young AI 

PROVIDER: S-EPMC9197765 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature