Infant formula containing bovine milk-derived oligosaccharides supports age-appropriate growth and improves stooling pattern.

ABSTRACT:

Background

Adding bovine milk-derived oligosaccharides (MOS) enhances the oligosaccharide profile of infant formula. This study aimed to evaluate the safety and efficacy of a MOS-supplemented infant formula.

Methods

In this double-blind randomized controlled trial, healthy infants 21-26 days old were either assigned to bovine milk-based, alpha-lactalbumin, and sn-2 palmitate enriched infant formula (control, n = 115) or the same formula with 7.2 g MOS/L (test, n = 115) until aged 6 months. Co-primary endpoints were weight gain through 4 months and stool consistency (validated scale: 1 = watery to 5 = hard). Secondary endpoints included parent-reported GI tolerance, health-related quality of life (HRQoL), and adverse events (AEs).

Results

Weight gain was similar (p = 0

SUBMITTER: Estorninos E 

PROVIDER: S-EPMC9197766 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature