Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver.

ABSTRACT: Liver development is a complex process that is regulated by a series of signaling pathways. Three-dimensional (3D) chromatin architecture plays an important role in transcriptional regulation; nonetheless, its dynamics and role in the rapid transition of core liver functions during development and obesity-induced metabolic stress remain largely unexplored. To investigate the dynamic chromatin architecture during liver development and under metabolic stress, we generated high-resolution maps of chromatin architecture for porcine livers across six major developmental stages (from embryonic day 38 to the adult stage) and under a high-fat diet-induced obesity. The characteristically loose chromatin architecture supports a highly plastic genome organization during early liver development, which

SUBMITTER: Chen L 

PROVIDER: S-EPMC9197842 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature