The Effects of Solid Particle Containing Inks on the Printing Quality of Porous Pharmaceutical Structures Fabricated by 3D Semi-Solid Extrusion Printing.

ABSTRACT:

Purpose

Semi-solid extrusion (SSE) 3D printing has potential pharmaceutical applications for producing personalised medicine. However, the effects of ink properties and drug incorporation on the quality of printed medication have not been thoroughly studied, particularly for porous geometries. This study aimed to investigate the effects of the presence of solid drug particles in SSE inks on the printing quality of porous structures.

Method

The rheological behaviour of model inks of paracetamol (PCM)-hypromellose (HPMC) with different drug loadings were investigated and correlated to their printing qualities.

Results

For the inks with PCM loading above the drug solubility in which suspended solid drug particulates were present, the results confirmed that PCM loading an

SUBMITTER: Teoh XY 

PROVIDER: S-EPMC9197916 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature