AMC-070: Lenalidomide Is Safe and Effective in HIV-Associated Kaposi Sarcoma.

ABSTRACT:

Purpose

Kaposi sarcoma (KS), an endothelial cell tumor associated with KS herpesvirus (KSHV), remains among the most common malignancies occurring with HIV infection (HIV-KS). As an oral anti-inflammatory, antiangiogenic, and immunomodulatory agent, lenalidomide is potentially an attractive alternative to standard chemotherapy for KS.

Experimental design

The primary objectives of this phase I/II trial were to determine the maximum tolerated dose (MTD) and response rates for lenalidomide in HIV-KS. Secondary objectives included correlating response with natural killer (NK) and T-cell subsets, plasma cytokines, viral copy number, and KSHV gene expression in biopsies. Four dose levels of oral lenalidomide taken 21 consecutive days of 28-day cycles were evaluated in adults with

SUBMITTER: Reid EG 

PROVIDER: S-EPMC9197984 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature