Muscle mass affects paclitaxel systemic exposure and may inform personalized paclitaxel dosing.

ABSTRACT:

Aims

Patients with low muscle mass have increased risk of paclitaxel-induced peripheral neuropathy, which is dependent on systemic paclitaxel exposure. Dose optimization may be feasible through the secondary use of radiologic data for body composition. The objective of this study was to interrogate morphomic parameters as predictors of paclitaxel pharmacokinetics to identify alternative dosing strategies that may improve treatment outcomes.

Methods

This was a secondary analysis of female patients with breast cancer scheduled to receive 80 mg/m² weekly paclitaxel infusions. Paclitaxel was measured at the end of initial infusion to estimate maximum concentration (C_max ). Computed tomography (CT) scans were used to measure 29 body composition features for

SUBMITTER: Hertz DL 

PROVIDER: S-EPMC9197985 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature