Small dense low-density lipoprotein particles: clinically relevant?

ABSTRACT:

Purpose of review

Levels of small, dense low-density lipoprotein (LDL) (sdLDL) particles determined by several analytic procedures have been associated with risk of atherosclerotic cardiovascular disease (ASCVD). This review focuses on the clinical significance of sdLDL measurement.

Recent findings

Results of multiple prospective studies have supported earlier evidence that higher levels of sdLDL are significantly associated with greater ASCVD risk, in many cases independent of other lipid and ASCVD risk factors as well as levels of larger LDL particles. A number of properties of sdLDL vs. larger LDL, including reduced LDL receptor affinity and prolonged plasma residence time as well as greater oxidative susceptibility and affinity for arterial proteoglycans, are consistent

SUBMITTER: Krauss RM 

PROVIDER: S-EPMC9197986 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature