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Regional CAR T cell therapy: An ignition key for systemic immunity in solid tumors.

ABSTRACT: The success of chimeric antigen receptor (CAR) T cell therapy in solid tumors, unlike in hematologic malignancies, is limited by inadequate tumor infiltration and T cell dysfunction and exhaustion. Regional delivery of CAR T cells in patients with solid tumors is safe and feasible; promotes infiltration, proliferation, and trafficking; and ignites functionally persisting systemic immunity.

SUBMITTER: Cherkassky L

PROVIDER: S-EPMC9197990 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Regional CAR T cell therapy: An ignition key for systemic immunity in solid tumors.

Cherkassky Leonid L Hou Zhaohua Z Amador-Molina Alfredo A Adusumilli Prasad S PS

Cancer cell 20220428 6

The success of chimeric antigen receptor (CAR) T cell therapy in solid tumors, unlike in hematologic malignancies, is limited by inadequate tumor infiltration and T cell dysfunction and exhaustion. Regional delivery of CAR T cells in patients with solid tumors is safe and feasible; promotes infiltration, proliferation, and trafficking; and ignites functionally persisting systemic immunity. ...[more]

PMID: 35487216

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