Regional CAR T cell therapy: An ignition key for systemic immunity in solid tumors.

ABSTRACT: The success of chimeric antigen receptor (CAR) T cell therapy in solid tumors, unlike in hematologic malignancies, is limited by inadequate tumor infiltration and T cell dysfunction and exhaustion. Regional delivery of CAR T cells in patients with solid tumors is safe and feasible; promotes infiltration, proliferation, and trafficking; and ignites functionally persisting systemic immunity.

SUBMITTER: Cherkassky L 

PROVIDER: S-EPMC9197990 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature