Long-term Survival after Hematopoietic Cell Transplant for Sickle Cell Disease Compared to the United States Population.

ABSTRACT: Hematopoietic cell transplant for sickle cell disease is curative but is associated with life threatening complications most of which occur within the first 2 years after transplantation. In the current era with interest in gene therapy and gene editing we felt it timely to report on sickle cell disease transplant recipients who were alive for at least 2-year after transplantation, not previously reported. Our objectives were to (1) report the conditional survival rates of patients who were alive for 2 or more years after transplantation (2) identify risk factors for death beyond 2 years after transplantation and (3) compare all-cause mortality risks to those of an age-, sex- and race-matched general population in the United States. By limiting to 2-year survivors, we exclude deaths that o

SUBMITTER: St Martin A 

PROVIDER: S-EPMC9198002 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature