Youth with Down syndrome display widespread increased functional connectivity during rest.

ABSTRACT: Studies of resting-state functional connectivity in young people with Down syndrome (DS) have yielded conflicting results. Some studies have found increased connectivity while others have found a mix of increased and decreased connectivity. No studies have examined whole-brain connectivity at the voxel level in youth with DS during an eyes-open resting-state design. Additionally, no studies have examined the relationship between connectivity and network selectivity in youth with DS. Thus, the current study sought to fill this gap in the literature. Nineteen youth with DS (M_age = 16.5; range 7-23; 13 F) and 33 typically developing (TD) youth (M_age = 17.5; range 6-24; 18 F), matched on age and sex, completed a 5.25-min eyes-open resting-state fMRI scan. Whole-brain func

SUBMITTER: Csumitta KD 

PROVIDER: S-EPMC9198034 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature