A dual-center cohort study on the association between early deep sedation and clinical outcomes in mechanically ventilated patients during the COVID-19 pandemic: The COVID-SED study.

ABSTRACT:

Background

Mechanically ventilated patients have experienced greater periods of prolonged deep sedation during the coronavirus disease (COVID-19) pandemic. Multiple studies from the pre-COVID era demonstrate that early deep sedation is associated with worse outcome. Despite this, there is a lack of data on sedation depth and its impact on outcome for mechanically ventilated patients during the COVID-19 pandemic. We sought to characterize the emergency department (ED) and intensive care unit (ICU) sedation practices during the COVID-19 pandemic, and to determine if early deep sedation was associated with worse clinical outcomes.

Study design and methods

Dual-center, retrospective cohort study conducted over 6 months (March-August, 2020), involving consecutive, mechanically ve

SUBMITTER: Stephens RJ 

PROVIDER: S-EPMC9198202 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature