Development of a Platelet-Related Prognostic Model for Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) represents one of the most common malignancies with high morbidity worldwide. Growing evidence has suggested that platelets are a fundamental component of the tumor microenvironment and play crucial roles in driving tumor biological behavior. The construction of a platelet-related prognostic model that can reliably predict CRC prognosis is of great clinical significance. The 1427 CRC-specific platelet-related genes were collected and mainly enriched in the ribosome and immune-related pathways. Based on platelet-related genes, three subtypes of TCGA CRC samples were identified by consensus clustering and characterized by differences in angiogenesis, epithelial-mesenchymal transition, immune infiltration, and prognosis. A total of 100 prognostic platelet-related genes

SUBMITTER: Wang P 

PROVIDER: S-EPMC9198283 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature