Significance of Placental Mesenchymal Stem Cell in Placenta Development and Implications for Preeclampsia.

ABSTRACT: The well-developed placentation is fundamental for the reproductive pregnancy while the defective placental development is the pathogenetic basis of preeclampsia (PE), a dangerous complication of pregnancy comprising the leading causes of maternal and perinatal morbidity and mortality. Placenta-derived mesenchymal stem cells (PMSCs) are a group of multipotent stem cells that own a potent capacity of differentiating into constitutive cells of vessel walls. Additionally, with the paracrine secretion of various factors, PMSCs inextricably link and interact with other component cells in the placenta, collectively improving the placental vasculature, uterine spiral artery remolding, and uteroplacental interface immunoregulation. Recent studies have further indicated that preeclamptic PMSCs, clo

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9198303 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature