Advances in the systemic treatment of therapeutic approaches in biliary tract cancer.

ABSTRACT:

Introduction

Biliary tract cancers (BTCs) are a rare and heterogenous group with an increasing incidence and high mortality rate. The estimated new cases and deaths of BTC worldwide are increasing, but the incidence and mortality rates in South East Asia are the highest worldwide, representing a real public health problem in these regions. BTC has a poor prognosis with a median overall survival <12 months. Thus, an urgent unmet clinical need for BTC patients exists and must be addressed.

Results

The backbone treatment of these malignancies is chemotherapy in first- and second-line setting, but in the last decade a rich molecular landscape has been discovered, expanding conceivable treatment options. Some druggable molecular aberrations can be treated with new targeted therap

SUBMITTER: Mirallas O 

PROVIDER: S-EPMC9198382 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature