A Novel In Silico Electromechanical Model of Human Ventricular Cardiomyocyte.

ABSTRACT: Contractility has become one of the main readouts in computational and experimental studies on cardiomyocytes. Following this trend, we propose a novel mathematical model of human ventricular cardiomyocytes electromechanics, BPSLand, by coupling a recent human contractile element to the BPS2020 model of electrophysiology. BPSLand is the result of a hybrid optimization process and it reproduces all the electrophysiology experimental indices captured by its predecessor BPS2020, simultaneously enabling the simulation of realistic human active tension and its potential abnormalities. The transmural heterogeneity in both electrophysiology and contractility departments was simulated consistent with previous computational and in vitro studies. Furthermore, our model could capture delayed a

SUBMITTER: Bartolucci C 

PROVIDER: S-EPMC9198403 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature