Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder defined by the progressive formation and spread of fibrillar aggregates of Aβ peptide and tau protein. Polymorphic forms of these aggregates may contribute to disease in varying ways since different neuropathologies appear to be associated with different sets of fibrillar structures and follow distinct pathological trajectories that elicit characteristic clinical phenotypes. The molecular mechanisms underlying the spread of these aggregates in disease may include nucleation, replication, and migration all of which could vary with polymorphic form, stage of disease, and region of brain. Given the linkage between mechanisms of progression and distribution of polymorphs, mapping the distribution of fibrillar structures in situ ha

SUBMITTER: Bashit AA 

PROVIDER: S-EPMC9198601 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature