The Cross-Species Immunity During Acute Babesia Co-Infection in Mice.

ABSTRACT: Babesiosis causes high morbidity and mortality in immunocompromised individuals. An earlier study suggested that lethal Babesia rodhaini infection in murine can be evaded by Babesia microti primary infection via activated macrophage-based immune response during the chronic stage of infection. However, whether the same immune dynamics occur during acute B. microti co-infection is not known. Hence, we used the mouse model to investigate the host immunity during simultaneous acute disease caused by two Babesia species of different pathogenicity. Results showed that B. microti primary infection attenuated parasitemia and conferred immunity in challenge-infected mice as early as day 4 post-primary infection. Likewise, acute Babesia co-infection u

SUBMITTER: Zafar I 

PROVIDER: S-EPMC9198632 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature