Sex Differences in the Risk of First and Recurrent Ventricular Tachyarrhythmias Among Patients Receiving an Implantable Cardioverter-Defibrillator for Primary Prevention.

ABSTRACT:

Importance

Current guidelines for primary implantable cardioverter-defibrillator (ICD) therapy do not account for sex differences in arrhythmic risk in ICD candidates.

Objective

To evaluate the association between sex and risk of ventricular tachyarrhythmia (VTA) and mortality.

Design, setting, and participants

This cohort study compared differences in the risk of VTA and mortality between 4506 men and women enrolled in the 4 Multicenter Automatic Defibrillator Implantation Trials (MADIT) between July 1, 1997, and December 31, 2011. Data from prospective randomized controlled multicenter studies were analyzed retrospectively. Men and women with an ICD or cardiac resynchronization therapy defibrillator who were enrolled in all MADIT studies were included. Data were ana

SUBMITTER: Saxena S 

PROVIDER: S-EPMC9198764 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature