Dissecting platelet proteomics to understand the pathophysiology of immune thrombocytopenia: studies in mouse models.

ABSTRACT: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by enhanced platelet clearance and defective platelet production. Diagnosis by exclusion and trial-and-error treatment strategies is common practice, and despite the advancement in treatment options, many patients remain refractory. Although the existence of different pathophysiological entities is acknowledged, we are still far from stratifying and understanding ITP. To investigate, we sought to dissect the platelet proteome dynamics in so-called passive and active preclinical ITP mouse models, with which we propose to phenocopy respectively acute/newly diagnosed and persistent/chronic stages of ITP in humans. We obtained the platelet proteome at the thrombocytopenic stage and after platelet count recovery (reached natur

SUBMITTER: Martinez-Botia P 

PROVIDER: S-EPMC9198918 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature