The Role of Tissue-Resident Macrophages in the Development and Treatment of Inflammatory Bowel Disease.

ABSTRACT: Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a refractory disease with many immune abnormalities and pathologies in the gastrointestinal tract. Because macrophages can distinguish innocuous antigens from potential pathogens to maintain mucosa barrier functions, they are essential cells in the intestinal immune system. With numerous numbers in the intestinal tract, tissue-resident macrophages have a significant effect on the constant regeneration of intestinal epithelial cells and maintaining the immune homeostasis of the intestinal mucosa. They also have a significant influence on IBD through regulating pro-(M1) or anti-inflammatory (M2) phenotype polarization according to different environmental cues. The disequilibrium of the phenotypes and functi

SUBMITTER: Ma S 

PROVIDER: S-EPMC9199005 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature