Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women.

ABSTRACT:

Background

Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising progesterone can prevent breast cancers in humans. We suggest that targeting progesterone signalling could be a means of reducing features which are known to promote breast cancer formation.

Methods

In healthy premenopausal women with and without a BRCA mutation we studied (i) estrogen and progesterone levels in saliva over an entire menstrual cycle (n = 20); (ii) cancer-free normal breast-tissue from a control population who had no family or personal history of breast cancer and equivalently from BRCA1/2 mutation carriers (n = 28); triple

SUBMITTER: Bartlett TE 

PROVIDER: S-EPMC9199133 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature