Mechanistic insight of the potential of geraniol against Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) as a neurodegenerative disease occupies 3/5-4/5 cases among patients with dementia, yet its pathogenetic mechanism remains unclear. Geraniol, on the other hand, is a well-known extract from essential oils of aromatic plants and has been proven that it has outstanding neuroprotective effects as well as ameliorating influence in memory impairment. Therefore, the present study aims to elucidate the potential of geraniol against AD by network pharmacology-based approach combined with molecular modeling study.

Materials and methods

Firstly, we evaluated the druggability of geraniol by ADME method. Then, we obtained the geraniol targets and AD-related targets from multiple open data sources. Afterward, we calculated the intersection through a Ve

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9199166 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature