Ontology highlight
ABSTRACT:
SUBMITTER: Cronan JE
PROVIDER: S-EPMC9199407 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Microbiology and molecular biology reviews : MMBR 20220418 2
Cyclopropane fatty acid (CFA) synthase catalyzes a remarkable reaction. The <i>cis</i> double bonds of unsaturated fatty acyl chains of phospholipid bilayers are converted to cyclopropane rings by transfer of a methylene moiety from S-adenosyl-L-methionine (SAM). The substrates of this modification are functioning membrane bilayer phospholipids. Indeed, in Escherichia coli the great bulk of phospholipid synthesis occurs during exponential growth phase, but most cyclopropyl synthesis occurs in ea ...[more]