Adaptive Metabolism of Staphylococcus aureus Revealed by Untargeted Metabolomics.

ABSTRACT: Staphylococcus aureus (SA) is an opportunistic pathogen that can cause a wide spectrum of infections, from superficial skin inflammation to severe and potentially fatal and invasive diseases. Due to the many potential routes of infection, host-derived environmental signals (oxygen availability, nutrients, etc.) are vital for host colonization and thus contribute to SA's pathogenesis. To uncover the direct effects of environmental factors on SA metabolism, we performed a series of experiments in diverse culture environments and correlated our findings of SA's metabolic adaptation to some of the pathogen's known virulence factors. Untargeted metabolomics was conducted on a Thermo Q-Exactive high-resolution mass spectrometer. We detected 260 intracellular polar metabolites from our bac

SUBMITTER: Choueiry F 

PROVIDER: S-EPMC9199441 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature