Single Cell Transcriptomic Analysis Reveals Organ Specific Pericyte Markers and Identities.

ABSTRACT: Pericytes are mesenchymal-derived mural cells that wrap around capillaries and directly contact endothelial cells. Present throughout the body, including the cardiovascular system, pericytes are proposed to have multipotent cell-like properties and are involved in numerous biological processes, including regulation of vascular development, maturation, permeability, and homeostasis. Despite their physiological importance, the functional heterogeneity, differentiation process, and pathological roles of pericytes are not yet clearly understood, in part due to the inability to reliably distinguish them from other mural cell populations. Our study focused on identifying pericyte-specific markers by analyzing single-cell RNA sequencing data from tissue-specific mouse pericyte populations generat

SUBMITTER: Baek SH 

PROVIDER: S-EPMC9199463 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature