Caecal microbiota composition of experimental inbred MHC-B lines infected with IBV differs according to genetics and vaccination.

ABSTRACT: Interactions between the gut microbiota and the immune system may be involved in vaccine and infection responses. In the present study, we studied the interactions between caecal microbiota composition and parameters describing the immune response in six experimental inbred chicken lines harboring different MHC haplotypes. Animals were challenge-infected with the infectious bronchitis virus (IBV), and half of them were previously vaccinated against this pathogen. We explored to what extent the gut microbiota composition and the genetic line could be related to the immune response, evaluated through flow cytometry. To do so, we characterized the caecal bacterial communities with a 16S rRNA gene amplicon sequencing approach performed one week after the IBV infectious challenge. We observed s

SUBMITTER: Borey M 

PROVIDER: S-EPMC9199466 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature