Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis.

ABSTRACT:

Background

Shorter telomere length is associated with numerous comorbidities. Several studies have investigated the role of obesity in telomere shortening. In the current systematic review and meta-analysis, we summarized the results of studies that evaluated the association between obesity and telomere length.

Methods

A systematic search from Scopus, PubMed, Embase, and ProQuest electronic databases up to 19 March 2021 without language restriction was performed and after data extraction and screening, 19 manuscripts were eligible to be included in the final meta-synthesis.

Results

The highest category of telomere length was associated with an approximate 0.75 kg/m² reduction in body mass index (BMI; WMD = -0.75 kg/m²; CI = -1.19, -0.31; p

SUBMITTER: Khosravaniardakani S 

PROVIDER: S-EPMC9199514 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature