Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study.

ABSTRACT: Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of green tea intake (N = 64,949), age at onset (N = 28,568) and progression (N = 4,093) of PD. One standard deviation increase in genetically determined green tea intake was significantly associated with slower progression to dementia (OR: 0.87, 95% CI: 0.81-0.94, P: 3.48E-04) after the Bonferroni correction. Meanwhile, higher green tea intake was nominally associated with slower progressio

SUBMITTER: Li C 

PROVIDER: S-EPMC9199515 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature