Prognostic impact of pleural effusion in patients with malignancy: A systematic review and meta-analysis.

ABSTRACT: The exact role of pleural effusion in the prognosis of cancer patients remains unclear. We aimed to systematically review the prognostic value of pleural effusion in patients with cancer. We performed a systematic review and meta-analysis with a systematic literature search. All cohort studies with available overall survival (OS) and progression-free survival (PFS) results for patients with cancer with or without pleural effusion were included. The Mantel-Haenszel method was used to calculate the pooled hazard ratios (HRs) and 95% confidence intervals (CIs). Heterogeneity and publication bias were examined. Subgroup analysis and sensitivity analysis were performed. A total of 47 studies with 146,117 patients were included in the analysis. For OS, pleural effusion was a prognostic factor as

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9199884 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature