Normothermic blood polarizing versus depolarizing cardioplegia in a porcine model of cardiopulmonary bypass.

ABSTRACT:

Objectives

We have previously demonstrated beneficial cardiac protection with hypothermic polarizing cardioplegia compared to a hyperkalemic depolarizing cardioplegia. In this study, a porcine model of cardiopulmonary bypass was used to compare the protective effects of normothermic blood-based polarizing and depolarizing cardioplegia during cardiac arrest.

Methods

Thirteen pigs were randomized to receive either normothermic polarizing (n = 8) or depolarizing (n = 5) blood-based cardioplegia. After initiation of cardiopulmonary bypass, normothermic arrest (34°C, 60 min) was followed by 60 min of on-pump and 90 min of off-pump reperfusion. Primary outcome was myocardial injury measured as arterial myocardial creatine kinase concentration. Secondary outcome was haemodynamic fu

SUBMITTER: Kramer AM 

PROVIDER: S-EPMC9199933 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature