Ontology highlight
ABSTRACT:
SUBMITTER: Domingo-Reines J
PROVIDER: S-EPMC9200071 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Domingo-Reinés Joan J Martínez-Navajas Gonzalo G Montes Rosa R Lamolda Mar M Simón Iris I Castaño Julio J Ríos-Pelegrina Rosa R Lopez-Hidalgo Javier Luis JL García Del Moral Raimundo R Marchal Juan A JA Real Pedro J PJ Ramos-Mejía Verónica V
Frontiers in cell and developmental biology 20220601
Pediatric acute myeloid leukemia (AML) is a rare and heterogeneous disease that remains the major cause of mortality in children with leukemia. To improve the outcome of pediatric AML we need to gain knowledge on the biological bases of this disease. NUP98-KDM5A (NK5A) fusion protein is present in a particular subgroup of young pediatric patients with poor outcome. We report the generation and characterization of human Embryonic Stem Cell (hESC) clonal lines with inducible expression of NK5A. Te ...[more]