Tet2 coordinates with Foxo1 and Runx1 to balance T follicular helper cell and T helper 1 cell differentiation.

ABSTRACT: In response to various types of infection, naïve CD4⁺ T cells differentiate into diverse helper T cell subsets; however, the epigenetic programs that regulate differentiation in response to viral infection remain poorly understood. Demethylation of CpG dinucleotides by Tet methylcytosine dioxygenases is a key component of epigenetic programing that promotes specific gene expression, cellular differentiation, and function. We report that following viral infection, Tet2-deficient CD4⁺ T cells preferentially differentiate into highly functional germinal center T follicular helper (T_FH) cells that provide enhanced help for B cells. Using genome-wide DNA methylation and transcription factor binding analyses, we find that Tet2 coordinates with multiple transcript

SUBMITTER: Baessler A 

PROVIDER: S-EPMC9200277 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature