Autonomous push button-controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant.

ABSTRACT: Traceless physical cues are desirable for remote control of the in situ production and real-time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic, magnetogenetic, or electrogenetic devices require sophisticated electronics, complex artificial intelligence-assisted software, and external energy supplies for power and control. Here, we describe a self-sufficient subcutaneous push button-controlled cellular implant powered simply by repeated gentle finger pressure exerted on the overlying skin. Pushing the button causes transient percutaneous deformation of the implant's embedded piezoelectric membrane, which produces sufficient low-voltage energy inside a semi-permeable platinum-coated cell chamber to mediate rapid release of a biopharmaceutical from enginee

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9200281 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature