Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced T_reg differentiation via up-regulating Nr4a2.

ABSTRACT: Steroid nuclear receptor coactivator 2 (SRC2) is a member of a family of transcription coactivators. While SRC1 inhibits the differentiation of regulatory T cells (T_regs) critical for establishing immune tolerance, we show here that SRC2 stimulates T_reg differentiation. SRC2 is dispensable for the development of thymic T_regs, whereas naive CD4⁺ T cells from mice deficient of SRC2 specific in T_regs (SRC2^fl/fl/Foxp3^YFP-Cre) display defective T_reg differentiation. Furthermore, the aged SRC2^fl/fl/Foxp3^YFP-Cre mice spontaneously develop autoimmune phenotypes including enlarged spleen and lung inflammation infiltrated with IFNγ-producing CD4⁺ T cells. SRC2

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9200286 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature