SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs.

ABSTRACT: Regulation of chromatin structure and accessibility determines the transcription activities of genes, which endows the host with function-specific patterns of gene expression. Upon viral infection, the innate immune responses provide the first line of defense, allowing rapid production of variegated antiviral cytokines. Knowledge on how chromatin accessibility is regulated during host defense against viral infection remains limited. Our previous work found that the nuclear matrix protein SAFA surveilled viral RNA and regulated antiviral immune genes expression. However, how SAFA regulates the specific induction of antiviral immune genes remains unknown. Here, through integration of RNA-seq, ATAC-seq and ChIP-seq assays, we found that the depletion of SAFA specifically decreased the chromat

SUBMITTER: Cao L 

PROVIDER: S-EPMC9200321 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature