Strategies and Tactics for the Development of Selective Glycan-Binding Proteins.

ABSTRACT: The influences of glycans impact all biological processes, disease states, and pathogenic interactions. Glycan-binding proteins (GBPs), such as lectins, are decisive tools for interrogating glycan structure and function because of their ease of use and ability to selectively bind defined carbohydrate epitopes and glycosidic linkages. GBP reagents are prominent tools for basic research, clinical diagnostics, therapeutics, and biotechnological applications. However, the study of glycans is hindered by the lack of specific and selective protein reagents to cover the massive diversity of carbohydrate structures that exist in nature. In addition, existing GBP reagents often suffer from low affinity or broad specificity, complicating data interpretation. There have been numerous efforts to expan

SUBMITTER: Ward EM 

PROVIDER: S-EPMC9200409 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature