Melatonin Alleviates PM_2.5-Induced Hepatic Steatosis and Metabolic-Associated Fatty Liver Disease in ApoE^-/- Mice.

ABSTRACT:

Background

Exposure to fine particulate matter (PM_2.5) is associated with the risk of developing metabolic-associated fatty liver disease (MAFLD). Melatonin is the main secreted product of the pineal gland and has been reported to prevent hepatic lipid metabolism disorders. However, it remains uncertain whether melatonin could protect against PM_2.5-induced MAFLD.

Methods and results

The purpose of our study was to investigate the mitigating effects of melatonin on hepatic fatty degeneration accelerated by PM_2.5 in vivo and in vitro. Histopathological analysis and ultrastructural images showed that PM_2.5 induced hepatic steatosis and lipid vacuolation in ApoE^-/- mice, which could be effectively alleviated by melatonin adm

SUBMITTER: Du Z 

PROVIDER: S-EPMC9200552 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature