Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review.

ABSTRACT: Background For decades, vitamin K antagonists and specifically warfarin, have been the sole agents used orally to manage thromboembolic conditions, including stroke and venous thromboembolism (VTE). Several factors lead to warfarin dose variability, including genetic and non-genetic factors which made warfarin management challenging especially at the initiation phase. To overcome the challenges with warfarin dosing at initiation, strategies other than conventional or fixed dosing were introduced and explored. Aim In this narrative review, we aim to discuss and critique the different dosing strategies for warfarin at initiation with more focus on genotype-guided warfarin dosing and the most recent supporting evidence for and against its use. Method Medline database was searched from 1965 to

SUBMITTER: Fahmi AM 

PROVIDER: S-EPMC9200678 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature