Identification of a novel prognostic signature for HCC and analysis of costimulatory molecule-related lncRNA AC099850.3.

ABSTRACT: Costimulatory molecules are involved in initiation of anti-tumor immune responses while long non-coding RNAs (lncRNAs) regulate the development of various cancers. However, the roles of lncRNA in hepatocellular carcinoma (HCC) have not been fully established. In this study, we aimed at identifying lncRNAs-related costimulatory molecules in HCC and to construct a prognostic signature for predicting the clinical outcomes for HCC patients. Data were downloaded from The Cancer Genome Atlas database for bioinformatics analyses. Costimulatory molecules were obtained from published literature. The R software, SPSS, and GraphPad Prism were used for statistical analyses. A risk model that is based on five costimulatory molecule-related lncRNAs was constructed using lasso and Cox regression analyses

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9200812 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature