Temporal mapping of derived high-frequency gene variants supports the mosaic nature of the evolution of Homo sapiens.

ABSTRACT: Large-scale estimations of the time of emergence of variants are essential to examine hypotheses concerning human evolution with precision. Using an open repository of genetic variant age estimations, we offer here a temporal evaluation of various evolutionarily relevant datasets, such as Homo sapiens-specific variants, high-frequency variants found in genetic windows under positive selection, introgressed variants from extinct human species, as well as putative regulatory variants specific to various brain regions. We find a recurrent bimodal distribution of high-frequency variants, but also evidence for specific enrichments of gene categories in distinct time windows, pointing to different periods of phenotypic changes, resulting in a mosaic. With a temporal classification of genetic mut

SUBMITTER: Andirko A 

PROVIDER: S-EPMC9200848 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature