Identification and Verification of Immune Subtype-Related lncRNAs in Clear Cell Renal Cell Carcinoma.

ABSTRACT:

Background

According to clinical study results, immune checkpoint blockade (ICB) treatment enhances the survival outcome of patients with clear cell renal cell carcinoma (ccRCC). Previous research has divided ccRCC patients into immune subtypes with distinct ICB response rates. However, the study on the association between lncRNAs and ccRCC immune subtypes is lacking.

Methods

Differentially expressed lncRNAs/mRNAs between two major immune subgroups were calculated. A weighted gene co-expression network analysis (WGCNA) was conducted to establish the lncRNA-mRNA co-expression network and select the key lncRNAs. Then, prognostic lncRNAs were selected from the network by the bioinformatics method. Next, the risk-score was estimated by lncRNA expression and their coefficients. F

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9200973 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature