Diagnostic Value of ¹⁸F-NOTA-FAPI PET/CT in a Rat Model of Radiation-Induced Lung Damage.

ABSTRACT: In this study, we explore the diagnostic value of a novel PET/CT imaging tracer that specifically targets fibroblast activation protein (FAP), ¹⁸F-NOTA-FAPI, in a radiation induced lung damage (RILD) rat model. High focal radiation (40, 60, or 90 Gy) was administered to a 5-mm diameter area of the right lung in Wistar rats for evaluation of RILD induction. Lung tissues exposed to 90 Gy radiation were scanned with ¹⁸F-NOTA-FAPI PET/CT and with ¹⁸F-FDG. Dynamic ¹⁸F-NOTA-FAPI PET/CT scanning was performed on day 42 post-irradiation. After in vivo scanning, lung cryosections were prepared for autoradiography, hematoxylin and eosin (HE) and immunohistochemical (IHC) staining. An animal model of RILD was established and validated by histopatholo

SUBMITTER: Qin X 

PROVIDER: S-EPMC9201039 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature