Clinical and Biological Significance of a Necroptosis-Related Gene Signature in Glioma.

ABSTRACT:

Background

As a novel form of programmed cell death, necroptosis is related to multiple tumor types and their immune microenvironments. However, its association with glioma has not been clarified.

Methods

Necroptosis genes were obtained from the Gene Set Enrichment Analysis (GSEA) database. RNA-seq and clinical data were downloaded from TCGA and CGGA databases. A necroptosis gene signature was constructed based on univariate and multivariate Cox regression analyses. Next, survival analysis, independent prognostic analysis, and nomogram were performed to assess and verify the model. Subsequently, we analyzed the tumor microenvironment (TME) and immune cell infiltration via ESTIMATE and CIBERSORTx algorithms. Finally, the response of glioma patients in the TCGA database

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC9201102 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature