Bothrops jararaca Snake Venom Inflammation Induced in Human Whole Blood: Role of the Complement System.

ABSTRACT: The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulopathy, shock, and acute kidney failure. The rapid development of local clinical manifestations is accompanied by the presence of mediators of the inflammatory process originating from tissues damaged by the bothropic venom. Considering the important role that the complement system plays in the inflammatory response, in this study, we analyzed the action of Bothrops jararaca snake venom on the complement system and cell surface receptors involved in innate immunity using an ex vivo human whole blood model. B. jararaca

SUBMITTER: Leonel TB 

PROVIDER: S-EPMC9201114 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature