Transcriptomics combined with metabolomics analysis of the mechanism of agmatine in the treatment of septic liver injury.

ABSTRACT:

Background

Acute liver injury can occur at any stage of sepsis and is an important sign of multiple organ dysfunction syndrome (MODS). Studies have shown that agmatine (AGM) can effectively improve liver injury caused by sepsis. However, due to the numerous metabolites and metabolic pathways of AGM in the human body, its mechanism in treating septic liver injury is unclear.

Methods

In this study, a liver injury model of septic Sprague-Dawley rats was established by cecal ligation and perforation (CLP). After AGM treatment, transcriptomics combined with metabolomics was employed to analyze the gene expression levels and metabolite changes.

Results

The results showed that AGM decreased the expression levels of alanine aminotransferase (ALT), aspartate aminotransferase (

SUBMITTER: Huang L 

PROVIDER: S-EPMC9201151 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature