Umbilical cord mesenchymal stem cells alleviate Sjogren's syndrome and related pulmonary inflammation through regulating Vγ4⁺ IL-17⁺ T cells.

ABSTRACT:

Background

Since gamma delta (γδ) T cells are involved in various autoimmune diseases, we aimed to verify whether γδ T cells participate in the pathogenesis of Sjögren's syndrome (SS) and related pulmonary inflammation, and also aimed to evaluate the effects of umbilical cord mesenchymal stem cells (MSCs) on SS-related pulmonary inflammation and the γδ T cells.

Methods

The saliva flow rates of female non-obese diabetic (NOD/Ltj) mice were measured. Histopathologic analysis was performed in salivary glands (SG) and lung tissues. The levels of γδ T cells and their subsets in the peripheral blood, spleen, and lung were examined by flow cytometry. The purified γδ T cells were adoptively transferred into NOD/Ltj mice. MSC transplantation was performed in 8-week-old NOD/Ltj mice.<

SUBMITTER: Cong Y 

PROVIDER: S-EPMC9201169 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature