GFAT1 is highly expressed in cancer stem cells of pancreatic cancer.

ABSTRACT:

Background

Cancer stem cells (CSCs) play pivotal roles in the growth, invasion, metastasis, and chemoresistance of pancreatic cancer (PC). The current characterization of CSCs in PC is not complete. Glutamine-fructose-6-phosphate transaminase 1 (GFAT1) is a key enzyme that regulates the hexosamine pathway (HP), in which it not only controls glucose influx but also catalyzes the reaction to form glucosamine 6-phosphate. Recently, it was reported that GFAT1 is highly expressed in PC. However, the relevance of this high expression of GFAT1, especially its association with cancer stemness, has not been well defined and is thus addressed in the current study.

Methods

GFAT1 levels were determined in PC from a public database and assessed by bioinformatics tools. GFAT1 expression i

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9201171 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature